Biological laboratories, also known as biosafety or biocontainment labs, are specialized facilities designed to safely handle hazardous biological agents. Through a combination of physical containment barriers and strict management protocols, these labs prevent or control the exposure of lab personnel and the environment to harmful organisms. They are essential for research in numerous fields, including virology, cell biology, animal studies, genetic recombination, microbiology, biomedicine, and biochemistry.

 

A typical biological laboratory consists of a main lab area and several auxiliary support rooms. Before beginning construction, it's crucial to understand the different types of biological labs, as each classification requires a unique design approach to meet specific safety and research needs.

 

Types of Biological Laboratories

 

PCR (Gene Amplification) Laboratory

A PCR (Polymerase Chain Reaction) laboratory is a molecular biology facility designed for amplifying specific DNA segments. This process, which can be thought of as a form of "in-vitro DNA replication," allows researchers to use a DNA gene tracking system to rapidly and accurately quantify viral loads in patients with nanoscale precision. Operating a PCR lab requires strict management systems, standardized operating procedures (SOPs), and comprehensive quality control documentation to ensure accurate results, biological safety, and long-term operational stability in compliance with health regulations.

 

HIV (AIDS) Laboratory

An HIV laboratory is dedicated to testing for the Human Immunodeficiency Virus (HIV) or its markers. These labs analyze human blood, bodily fluids, tissues, organs, and related biological products to detect the virus itself, its antigens, nucleic acids, or the corresponding antibodies.

 

Aseptic Laboratory

Often a small, isolated room (typically 4-5 square meters) within a larger microbiology lab, an aseptic lab is built with sealed materials like paneling and glass. It is preceded by a buffer room with offset doors to prevent airborne contaminants from entering. Both the aseptic room and buffer room are sealed and equipped with air handling systems that feature high-efficiency air filters. By establishing a sterile environment with sterile materials, researchers can study specific, known microorganisms without cross-contamination.

 

Cleanroom Laboratory

A cleanroom is a completely sealed environment where air quality is precisely controlled. An HVAC system circulates air through a series of pre-filters, medium-efficiency filters, and high-efficiency (HEPA) filters to maintain a controlled, low concentration of airborne particles. Key parameters controlled in a cleanroom include dust particle count, microbial colony count, air exchange rate, pressure differential, temperature, humidity, illumination, and noise levels.

 

Animal Laboratory (Vivarium)

Also known as an animal facility, this building is designed for housing and breeding laboratory animals under specific environmental conditions. Maintaining a controlled environment is critical to ensure the health of the animals and the accuracy of experimental results. Based on the level of microbial control, they are categorized into open systems, barrier systems, and isolator systems.

 

BSL-2 Laboratory

This refers to a Biosafety Level 2 laboratory. The World Health Organization (WHO) classifies infectious microorganisms into four risk groups based on their pathogenicity and transmission risk. Accordingly, biological laboratories are classified into four corresponding safety levels (BSL-1, BSL-2, BSL-3, and BSL-4), with BSL-4 being the highest. BSL-2 labs are suitable for work involving agents that pose a moderate potential hazard to personnel and the environment.

 

Microbiology Laboratory

A laboratory dedicated to the study of microorganisms. Its design differs significantly from general labs and requires specific safety features. A comprehensive microbiology lab typically includes a preparation room, washing area, sterilization room, aseptic room, constant-temperature incubation room, and a general lab area. Advanced facilities often incorporate cleanroom technology with filtered air, modular clean panels for walls and ceilings, and epoxy self-leveling floors, with clear separation between non-purified, gowning, and purified zones.

 

BSL-3 Laboratory

A Biosafety Level 3 laboratory is a high-containment facility. The entire lab is sealed and maintained under negative pressure to ensure that no air can leak out, thus preventing environmental contamination. BSL-3 labs are required for work with indigenous or exotic agents that can cause serious or potentially lethal disease through inhalation. Examples include SARS virus, Bacillus anthracis (anthrax), Yersinia pestis (plague), Mycobacterium tuberculosis, and Rabies virus.

 

For a growing number of medical laboratories, an integrated partnership model is proving to be a highly advantageous choice. The decision to adopt this collaborative business model is becoming increasingly straightforward, leading to wider acceptance across the medical lab sector.

 

However, selecting the right supplier for such a partnership demands a deeper understanding and careful consideration of various factors. In the existing landscape of integrated medical lab partnerships within the Chinese IVD market, we've observed instances where collaborations have fallen short of expectations. This includes issues such as:

• Subpar product quality: Products provided by suppliers failing to meet anticipated standards.
• Decreased service quality: The overall lab service standard declining, leading to operational hurdles.
• Unfulfilled promises: Significant deviations from or complete failure to deliver on initially promised services by suppliers.

 

These challenges don't stem from inherent flaws in the business model itself. Instead, they often arise because this is a relatively new commercial approach, and many suppliers are still in their growth phase. A supplier's capabilities and their core value proposition are crucial determinants of a partnership's success. While the integrated partnership model offers significant benefits for medical laboratories, the choice of supplier requires extreme caution.

 

 

Key Criteria for Selecting an Integrated Partnership Supplier

When choosing a supplier for an integrated partnership, a funnel-based assessment method can be highly effective. The initial stage of this funnel involves a preliminary screening of suppliers based on fundamental criteria, tailored to the specific needs of the hospital or lab. Three critical indicators in this initial phase are: supplier's comprehensive strength, service capabilities, and product integration capabilities.

 

 

Supplier's Comprehensive Strength: A Foundation for Sustainable Growth

• Scale and Size: "The strong get stronger." Companies with a certain scale and size tend to possess greater resilience against risks. Early success often signifies a company's robust strength and operational prowess. The number of clients a company serves frequently validates its recognition and approval from customers. Furthermore, for companies in the IVD industry, being publicly listed is a key indicator of their capabilities and future development potential.

 

• Growth Trajectory: Stable operations and sustained growth are vital indicators of a company's health. The IVD industry has seen cases of once high-growth companies experiencing rapid decline due to policy changes or market shifts. Maintaining a healthy growth rate over the past five years is a strong sign of a company's vitality.

 

• Reasonable Profit Margin: As industry competition intensifies, profit margins are generally decreasing. An excessively high profit margin might suggest insufficient investment in product development, innovation, or service. Conversely, an overly low profit margin could indicate inefficiencies in business management or even pose risks to future development.

 

 

Supplier's Professional Background: Defining Service Capabilities

A thorough evaluation of a supplier's professional capabilities in the in-vitro diagnostics field includes assessing:

 

Long-term engagement in IVD: Has the supplier been actively involved in the IVD sector for a significant period?

Experience across product platforms: Do they possess service experience across various product platforms?

Standardized service processes: Do they have well-defined and standardized service procedures?

Robust and stable service team: Do they have a strong and consistent service team?

Supplier's Development History: Reflecting Product Integration Capabilities

 

For laboratories, it's crucial to prioritize product assessment across key technical platforms like immunology, biochemistry, and clinical examination. Simultaneously, consider products for future development areas such as gene sequencing, based on your specific growth needs.

 

Furthermore, investigate the depth of the supplier's product partnerships with manufacturers. High-quality, long-term, and stable collaboration experiences often indicate a supplier's professional competence in product combination and mature service capabilities.

 

In an integrated partnership, potential supply issues might involve three-party contracts between manufacturers, distributors, and customers. It's essential to clearly define the responsibilities and rights of all parties involved in such contracts. Ideally, signing direct contracts with strong manufacturers is the most preferable option.

 

Advance International Corp: A Leader in Lab Logistics and Integrated Solutions

Advance International Corp is a key player in providing robust supply capabilities, particularly in the critical area of laboratory transportation. Our extensive experience and established network ensure reliable and efficient delivery of vital laboratory products. We understand the complexities of logistics within the IVD sector and are committed to streamlining the supply chain for our partners. By leveraging our expertise, medical laboratories can significantly enhance their operational efficiency and focus on delivering high-quality patient care.

In the fields of chemistry, pharmaceuticals, and related scientific research, Contract Research Organizations (CROs) are pivotal. They undertake crucial tasks like drug development, chemical synthesis, and analytical testing. A lesser-known but equally vital aspect of their role involves the meticulous selection and use of laboratory packaging materials. This isn't just about good practice; it’s fundamental for research integrity, regulatory compliance, safety, and ultimately, client trust.

 

Ensuring Sample Integrity with the Right Packaging

 

The stability and integrity of samples—whether they are chemicals, drug intermediates, or finished pharmaceuticals—are directly influenced by the quality of laboratory packaging materials. Inadequate packaging can lead to sample degradation, contamination, or changes in physical properties, all of which compromise the accuracy and reliability of experimental results. For CROs, this means understanding the nuances of how different materials interact with various samples. Products like 95kPa bags and specimen bags are critical for maintaining sample integrity during storage and transport, especially for sensitive biological or chemical materials that require pressure differential resistance.

 

Complying with Stringent Regulations and Standards

 

Drug development and chemical experiments operate under strict regulatory frameworks. Packaging materials must adhere to guidelines from organizations such as GMP (Good Manufacturing Practice), GLP (Good Laboratory Practice), FDA (US Food and Drug Administration), and ICH (International Council for Harmonisation). As a service provider, CROs must ensure their chosen packaging materials meet both client specifications and regulatory demands to avoid costly compliance risks. Using certified specimen bags and containers that meet these standards is non-negotiable for CROs.

 

Preventing Cross-Contamination in the Lab

 

Laboratories frequently handle a diverse array of active substances or sensitive compounds. Improper packaging can be a gateway for cross-contamination, jeopardizing experimental results and product safety. CROs must opt for packaging materials with excellent chemical inertness that won't leach harmful substances, ensuring a pristine experimental environment. This often involves specialized containers and sealing methods. The inclusion of an absorbent pad within packaging can further mitigate risks by containing spills and preventing contamination spread, especially crucial when dealing with potentially hazardous liquids.

 

Building Client Trust and Enhancing Service Quality

 

A CRO's service quality directly correlates with client trust and project success. The use of high-quality, professional laboratory packaging materials signals a CRO's meticulous attention to detail and professionalism. This boosts client confidence in the standardization and reliability of their laboratory operations, reinforcing their commitment to excellence.

 

Prioritizing Personnel and Environmental Safety

 

Certain chemicals are corrosive, toxic, or volatile. Substandard packaging can lead to leaks, volatilization, or direct human contact, posing significant risks. CROs who prioritize the safety of their packaging materials directly contribute to protecting laboratory personnel health and environmental safety, thereby reducing the likelihood of accidents. This includes selecting robust containers and ensuring proper sealing mechanisms. The strategic placement of an absorbent pad inside secondary packaging, like a 95kPa bag, offers an additional layer of safety by quickly absorbing any leaks from primary containers.

 

Supporting Long-Term Storage and Transportation Needs

 

The drug development pipeline often necessitates long-term sample storage or international transportation. CROs must select packaging materials that offer superior sealing, temperature resistance, and light resistance to ensure sample stability throughout these extended periods and diverse logistical challenges. Specialized specimen bags and 95kPa bags are designed to withstand varying pressures and temperatures, making them ideal for secure, long-distance transit.

 

By understanding and prioritizing these aspects of laboratory packaging, CROs not only uphold scientific integrity but also fortify their reputation as reliable, safe, and compliant partners in the vital journey of scientific discovery and drug development.

Understanding Dengue: A Guide to the Mosquito-Borne Virus

Introduction

 

Dengue is an acute arthropod-borne viral infection that places a heavy socioeconomic and disease burden on many tropical and subtropical regions, and is the most frequent arboviral disease globally. Dengue is transmitted by the bite of an infected female mosquito. Non-vector transmission can also occur, for example, through blood transfusion, organ transplantation, needle stick injuries, and mucosal splashes.Transmitted by mosquitoes of the genus Aedes, dengue is found mainly in the tropics and subtropics, with over 3 billion people living in Aedes-infested areas. The annual incidence of dengue infections was estimated to be around 400 million per year.

 

Clinical Manifestations of the Three Dengue Phases

Febrile Phase

 

• High fever and chills. Typically persistent or unremitting, although a saddleback pattern can be observed. Children experience high fever and vomiting but are usually less symptomatic than adolescents and adults, except that febrile convulsions can occur.

• Fever lasts for 3–7 days from illness onset.

• Systemic symptoms such as headache, malaise, retro-orbital pain, arthralgia, myalgia, bone pain, nausea, vomiting, and altered taste sensation.

• Presence of upper respiratory symptoms helps to differentiate influenza from dengue.

• Examination findings can include rash, flush, conjunctival or pharyngeal injection, mild bleeding manifestations, generalised lymphadenopathy, and a palpable liver.

• A tourniquet test can be positive but is a non-specific finding.

 

 

Critical Phase

 

Vascular leak syndrome, bleeding, liver impairment, CNS impairment, cardiac impairment, eye impairment, impairment of other organs (Microscopic haematuria has been noted in 20 –30% of inpatients with dengue but AKI is rare generally. Renal failure is sometimes seen in profound DSS, or in association with rhabdomyolysis.)

 

Recovery Phase

 

• With good supportive care full recovery is usual within 1–2 weeks.

• Post-viral fatigue and depression are reported, but few studies have evaluated these outcomes prospectively.

• A florid convalescent rash can develop, resolving slowly over several weeks.

• Fever persisting for >10 days can indicate bacterial superinfection or development of rare complications, such as secondary haemophagocytic lymphohistiocytosis.

 

 

 

Diagnosis

      * For Suspected Cases

 

Visit to a dengue-endemic area within 14 d prior to the onset of the disease, or the presence of dengue cases within 1 month around the place of residence or workplace, consistent with the clinical manifestations of dengue fever.

 

       * For Clinical Diagnostic Cases

 

Serum specimens from suspected cases tested positive for dengue virus IgM antibodies or positive for NS1 antigen.

 

 

       * For Confirmed Cases

 

Suspected cases or clinically diagnosed cases that meet one of the following: (1) Positive dengue virus nucleic acid test; (2) Culture isolation of dengue virus; (3) Positive seroconversion of dengue virus IgG antibodies in serum, or at least a fourfold rise in antibody titer during the convalescent phase as compared with the acute phase.

 

 

 

Laboratory Investigations

Etiological and Serological Examinations

 

Antigen Detection — Dengue virus NS1 antigen tests positive in blood during the acute febrile phase (By colloidal gold assay or ELISA)，NS1 is a glycoprotein that is common to all dengue serotypes and can be used to detect either primary or secondary infections in the earliest stages.

Nucleic Acid Detection — Dengue virus nucleic acid tests positive in specimens such as blood or cerebrospinal fluid (CSF).

Virus Isolation — Dengue virus is isolated via culture from specimens such as blood.

Serological Antibody Detection — Serology testing for dengue lgG and lgM can be useful in confirming primary or secondary diagnosis. IgM antibodies can be detected 3-5 days after symptom onset in primary infection patients, peak at 2 weeks, and persist for 2-3 months. A positive IgM test suggests recent dengue virus infection and is applicable for early diagnosis of dengue fever; however, cross-reactivity with other flaviviruses may occur. IgG antibodies can be detected approximately 1 week after symptom onset and may persist for years or even lifelong. Detection of high levels of IgG antibody within the first week of illness suggests a secondary infection.

General Examinations —Complete blood count (CBC), urinalysis, clinical chemistry tests, coagulation studies, ultrasonography, X-ray, CT, MRI, ECG and so on. All of the above can play a supportive role in diagnosis and treatment.

 

 

Getein’s Solutions

Getein offers dengue NS1 Ag rapid test for antigen detection and dengue lgG/lgM combo rapid test for serological antibody detection. Dengue NS1 antigen can be detected from the 1st day after onset of dengue symptoms, while dengue lgG/lgM combo can differentiate between primary & secondary dengue infection. Getein's solutions enable comprehensive diagnosis of dengue infection from acute to convalescent stages, requiring easy usage steps and only 15 minutes for result generation with high sensitivity and superior specificity. These relevant test kits are supported on our devices Getein 1100, Getein 1160, Getein 1180, Getein 1200, and Getein 1600. For more details, please visit our online website.

 

 

Are you experiencing unexplained weight loss, digestive problems, abdominal pain or jaundice? Don't ignore these symptoms, these may signal underlying liver issues! PIVKA-II testing helps identify hepatocellular carcinoma(HCC) risk, it’s a critical step towards early intervention through comprehensive diagnostic follow-up.

 

 

         What is PIVKA-II ？

 

Protein induced by Vitamin K absence or antagonist-II (PIVKA-II), also known as abnormal prothrombin, is an abnormal form of the blood-clotting protein prothrombin. Produced when vitamin K metabolism is disrupted (e.g., in liver cancer), PIVKA-II lacks gamma-carboxylation. Its elevated levels are a hallmark of hepatocellular carcinoma (HCC) and strongly correlate with tumor size, metastasis, and prognosis. Unlike AFP, PIVKA-II offers higher specificity for HCC, especially in AFP-negative cases.

 

          Why Choose PIVKA-II Testing ？

 

•Early HCC Detection: Identifies liver cancer earlier than imaging in high-risk patients. 

•Complement to AFP: Increases diagnostic accuracy when combined with alpha-fetoprotein (AFP) testing.

•Monitor Treatment Response: Tracks tumor progression or regression post-surgery/chemotherapy. 

•Predict Recurrence Risk: Rising levels signal potential cancer recurrence.

•Risk Stratification: Guides clinical decisions for cirrhosis or hepatitis patients. 

•Sample & Reliable: A quick, patient-friendly test for proactive liver health management.

 

 

          Who Should Get Tested？

 

•Chronic Liver Disease Patients: Cirrhosis, hepatitis B/C carriers. 

•AFP-negative HCC Suspects: When AFP results are inconclusive. 

•Post-HCC Treatment Patients:Monitoring recurrence after resection/ablation. 

•Family History of HCC: Genetic predisposition to liver cancer. 

•Unexplained Liver Dysfunction: Elevated ALT/AST with unknown cause. 

•High-risk Lifestyles: Long-term alcohol abuse or metabolic syndrome. 

•Pre-transplant Screening: Evaluating HCC risk in liver transplant candidates.  

•Vitamin K Deficiency Disorders:To rule out malignancy-linked abnormalities. 

•Surveillance Programs: Regular testing for cirrhosis/hepatitis patients.

 

Getein's Cares for 

PIVKA-II CLIA Platform

 

Getein supports your journey toward proactive liver health with precise, actionable insights! 

 

 

 

 

1. Rapidly establish intravenous access

Question: During emergency treatment (such as massive hemorrhage, shock, or cardiac arrest), rapid intravenous infusion or medication is required. However, the patient may experience vascular collapse due to dehydration, low blood pressure, or obesity, making it difficult to locate.

Function

Real-time display of subcutaneous veins (such as veins on the back of the hand and in front of the elbow) through infrared imaging can shorten the puncture time (studies show that it can reduce the number of attempts by 30-50%).

Avoid vascular damage or complications (such as hematoma) caused by repeated punctures.

Typical scenario

Emergency room rescue of patients with hemorrhagic shock.

Establish venous access for the wounded on the battlefield or at disaster sites.



2. Dealing with special patient groups

Children/Infants

Newborns have thin and fragile blood vessels. Vein-Finder can precisely locate them, reducing the pain of puncture (pediatric studies show a 40% increase in success rate).

Obese patients

The fat layer covers the veins, making traditional palpation difficult. The equipment can penetrate 10-15mm and clearly visualize the tissue.

Elderly/patients with chronic diseases

Long-term intravenous infusion can lead to vascular hardening or atrophy, and the device helps identify available venous segments.



3. Applications in harsh environments

Low light/Night rescue

When there is a power outage, in the wild or during night rescue, the device comes with its own light source and does not rely on external lighting (such as in earthquake-stricken areas or military operations).

Polluting the environment

Reduce operation time and lower exposure risks (such as in scenarios of chemical pollution or infectious diseases).



4. Reduce medical errors and the risk of infection

Function

Reduce needle contamination or occupational exposure of medical staff (such as HIV and hepatitis B viruses) caused by failed puncture.

Avoid phlebitis caused by repeated punctures, especially for emergency patients who need long-term intravenous infusion (such as those with sepsis).

Data support

An ICU study showed that the catheter-related infection rate decreased by 22% after the use of Vene-Finder.



5. Adaptation to special first aid scenarios

Burn patients

Skin damage makes it impossible to use a tourniquet. The device locates the remaining veins through non-contact imaging.

Hypothermia

When blood vessels constrict, infrared technology can still identify deep veins.

Diabetic emergency

Ketoacidosis requires rapid fluid replacement, but the patient's vascular condition is poor. The equipment can increase the success rate of the first puncture.

Also welcome to contact us, we are ZD Medical Inc.
Tel : +86-187 9586 9515
Email : sales@zd-med.com
Whatsapp/Mobile : +86-187 9586 9515

Exudative Retinal Detachment (ERD) is a lesion in which the neuroepithelial layer of the retina separates from the pigment epithelial layer without holes. The core mechanism is the destruction of the blood-retinal barrier or the imbalance of choroidal osmotic pressure, resulting in abnormal accumulation of plasma, lipids or blood in the subretinal space. Unlike rhegmatogenous or tractional detachment, ERD does not have retinal holes. ERD is often an "ocular crisis signal" of systemic or local diseases.

ERD is essentially the fundus manifestation of multi-system diseases, and its causes can be divided into two major categories:
(1) Systemic diseases and pregnancy-related diseases: Severe preeclampsia (S-PE) and HELLP syndrome are high-risk factors for ERD; Hypertensive nephropathy: Malignant hypertension can cause choroidal circulation disorders, and fibrinoid necrosis of choroidal arteriole leads to a large amount of plasma exudation. (2) Ocular diseases such as uveitis and retinal vasculitis: Uveitis ranks first among the causes of ERD, especially posterior uveitis like VOGT-Koyanagi-Harada syndrome (VKH) and sympathetic ophthalmia. Inflammation leads to increased permeability of choroidal vessels, causing exudation. Tuberculous uveitis can form subretinal abscesses or granulomas, directly damaging the blood-retinal barrier. Vascular diseases: Coats' disease - Highly prevalent in children and adolescents. Retinal capillary dilation accompanied by a large amount of lipid exudation can lead to total detachment. Retinal vein occlusion (BRVO) - Ischemic vein occlusion induces the release of inflammatory factors, leading to vascular leakage; Tumors and congenital abnormalities: Choroidal melanoma or hemangioma disrupts the blood-retinal barrier, leading to the accumulation of exudate. Metastatic breast cancer and lung cancer are the most common primary foci. According to the latest study of EURETINA 2024, exudative detachment is the main manifestation of invasive retinopathy of prematurity (ROP), accompanied by edema in the anvascular area and subretinal exudation.

The symptoms of ERD patients are diverse, but there are usually four key warning signs:
Painless vision loss: When the macular area is involved, vision can drop sharply to below 0.1. Unlike rhegmatogenous detachment, vision loss in ERD usually progresses more slowly, but patients in the acute phase of hypertensive crisis or VKH syndrome may lose central vision within a few hours. Visual distortion: Due to the displacement of photoreceptor cells caused by subretinal fluid, wavy distortion occurs when looking at straight lines. Amsler grid examination reveals typical grid distortion. Central dark spot: When the macular area is affected, a fixed black shadow appears in the center of the visual field, but the peripheral visual field remains relatively intact. Abnormal color vision and flashes: Inflammatory ERD (such as VOGT-Koyanagi-Harada disease) is prone to blue-yellow color vision shift.

Multimodal imaging combined application of optical coherence tomography (OCT) : The gold standard for ERD diagnosis, which can directly display low-reflection dark areas of subretinal fluid and RPE detachment. EDI-OCT technology - enhanced penetration depth, can quantify choroidal thickness, and help distinguish VKH from CSC; Fluorescein angiography (FFA) : Active leakage foci show "ink-stained" or "chimney-like" hyperfluorescence (such as CNV); The bleeding area shows fluorescence occlusion, and the non-perfusion area suggests ischemic etiology. Indocyanine green angiography (ICGA) : Evaluation of choroidal vessels - Diagnosis of polypoid choroidal vasculopathy (PCV) or VKH complex; OCT angiography (OCTA) : Non-invasive detection of retinal/choroidal neovascularization and quantification of blood flow density; B-type ultrasound: When the refractive media is turbid, it shows subretinal fluid dark areas, differentiating choroidal tumors or hemorrhage. Multifocal electroretinography (mfERG) : Objectively assess retinal functional impairment, especially suitable for children or uncooperative patients;

The treatment of ERD should focus on etiological therapy, supplemented by surgical intervention.

Drug therapy: Glucocorticoids - systemic or topical application (such as intrauterine injection) to suppress inflammation (such as uveitis, Eales' disease); Anti-vegf drugs - reduce vascular leakage (such as BRVO, Coats' disease); Laser and photocoagulation therapy: Retinal laser photocoagulation - sealing abnormal blood vessels (Coats' disease, ischemic BRVO); Micro-pulse laser - Treating macular edema and reducing thermal damage; Surgical intervention: It is only used for complex cases, such as vitrectomy when Coats' disease is secondary to traction detachment. Spontaneous absorption is possible. After blood pressure is controlled in hypertensive choroidal lesions, the detachment can spontaneously return to its original position. The prognosis is highly dependent on the control of the primary disease: inflammatory ERD - early hormone therapy can completely reset it, and the visual recovery is relatively good; Tumors or Coats' disease - Delayed diagnosis and treatment can cause permanent photoreceptor damage. Amblyopia should be vigilant in children. Follow-up requirements - OCT and FFA should be reexamined every 3 to 6 months to monitor recurrence.

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Example 1: The retinal neuroepithelial layer in the macular area protrudes, with dark reflex cavities inside

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Example 2: A mass of hyperreflectivity can be seen in the central area, accompanied by subretinal effusion and shallow detachment of the retinal pigment epithelium layer

Exudative retinal detachment is a "crisis signal" of systemic diseases within the eye, and its diagnosis and treatment require collaboration between ophthalmology and multiple disciplines. Early identification of the primary disease, combined multimodal imaging assessment, and targeted control of inflammation/vascular leakage are the core strategies to avoid permanent vision loss. Especially for premature infants and patients with chronic inflammation, regular fundus screening is a key line of defense for saving visual function!

Also welcome to contact us, we are ZD Medical Inc.
Tel : +86-187 9586 9515
Email : sales@zd-med.com
Whatsapp/Mobile : +86-187 9586 9515

In fast-paced manufacturing environments, keeping workspaces clean and safe is a non‑negotiable priority. Whether you’re tackling oil spills on the shop floor or wiping down delicate machinery, the right wiping solution makes all the difference. Our Industrial Paper Wiper delivers professional‑grade performance where lesser rags and shop towels simply can’t keep up. Designed for rigorous daily use, it helps you maintain productivity and hygiene without compromise.

Constructed from 100% pure wood pulp reinforced with a durable mesh scrim, this scrim‑grid composite offers exceptional strength and tear resistance—even when wet. Thanks to its eco‑friendly, fully biodegradable composition, you can rest assured that waste disposal stays green. With an absorption ratio of up to 1:6 and water‑hold capacity 500% greater than ordinary paper, each sheet locks in oil and liquids quickly and thoroughly, minimizing drips and drags on the production line.

Available in both 3‑layer and 4‑layer builds, our Scrim Paper Towel adjusts to your specific needs. Choose between 55 GSM for everyday wiping or 65 GSM for extra‑heavy‑duty spills. Sizes range from 30×30 cm to 50×60 cm, and three color options let you implement simple color‑coded cleaning protocols. Tested for tensile strength of 8–10 kg, this Scrim Reinforced Paper Hand Towel won’t fall apart under pressure—and if you require sterile wipes, customized sterilization services are also available.

As a cornerstone of industrial cleaning, these Industrial Wipes excel in automotive workshops, food processing plants, and electronics assembly lines alike. Their lint‑free surface makes them ideal for sensitive instruments, while the grid‑reinforced core provides the durability needed for scrubbing heavy soils and oils. Need branded packaging? Logo customization and FSC‑certified options are on offer to help you align with your company’s sustainability goals.

When you choose Industrial Paper Wiper, you’re not just investing in top‑tier materials—you’re partnering with the Telijie team. From rapid sample turnaround to tailored logistics solutions, our customer support ensures your facility never runs low. With decades of expertise, flexible order quantities, and a commitment to continuous innovation, Industrial Paper Wiper and Telijie together deliver reliability, responsiveness, and real results for every industrial cleaning challenge.

The development of surgical procedures is inseparable from the advancement of vessel sealing technology. With the improvement of living standards, patients demand higher standards in terms of the time required for haemostasis during surgery, as well as reduced damage, enhanced safety, and increased reliability. These demands have significantly driven the development of vessel sealing instruments.

 

A wide variety of vessel sealing instruments are now available on the market. These devices have different scopes of application. In actual use, it is necessary to select appropriate sealing instruments in response to specific vessel sealing requirements. This part depends on the doctor's experience. Frequent replacement of instruments also increases the doctor's workload and is not conducive to improving surgical efficiency. Some instruments have limited degrees of movement freedom at the end of device, making it difficult to grasp non-free blood vessels.

 

Research indicates that ergonomically designed laparoscopic instruments can significantly reduce the time surgeons take to complete hand-eye coordination tasks and improve their performance during laparoscopic surgery. Therefore, it is crucial to develop a vascular closure device that is widely applicable, easy to operate, and simple to use.

 

The AGISEAL series of vessel sealer dividers from ShouLiang-med aligns with the current trends in energy-based medical devices. It has a mature and precise energy control system, which can achieve accurate closure of blood vessels, improve the quality of tissue closure, and reduce thermal damage to normal tissues;its deeply optimized jaw design can achieve clamping in a larger size range and more precise tissue positioning; The multi-degree-of-freedom grasping, cutting, and closure-capable jaw tip maximises flexibility to meet the individualised operational needs of clinical practitioners. The ergonomic instrument handle greatly enhances surgeon comfort during operation, which is also key to improving surgical hemostasis efficiency.

 

[1] Wu Fei, Li Guixiang, Chen Jun, et al. Research status and development trend of vascular closure devices [J]. China Medical Devices, 2022, 37(4): 58-04.

[2] Kuang Yu, Li Wen, Ren Qianchuan. Comparative Analysis of Energy Instruments and Traditional Suture Technique in Transabdominal Cervical Cancer Surgery [J]. China Medical Devices, 2019, 34(3): 27-30.

[3] Qing Hongkun, Zhang Xiaoming, Jiang Jingjun, et al. Introduction to vascular closure devices [J]. Journal of Interventional Radiology, 2015, 24(6): 548-552

[4] Zhang Liqing, Song Shenghua, Wang Yuan, et al. Comparison of two-year follow-up of tonsillectomy with low-temperature plasma knife, ultrasonic knife and traditional method [J]. Journal of Otolaryngology and Ophthalmology of Shandong University, 2017, 31(5): 67-71.

Pregnancy-associated breast cancer (PABC) refers to breast cancer diagnosed during pregnancy or within one year postpartum, with an incidence of (2.4 to 7.3) cases per 100,000 pregnancies. Regarding the treatment of PABC, the international medical community currently believes that while continuing the pregnancy, necessary surgery and chemotherapy should be performed for the breast cancer, but the patient's and foetus's vital signs and changes in condition must be closely monitored throughout the entire process.

 

Chen Peng et al. mentioned in their paper "Application of electrosurgical equipment in operative treatment of PABC and the discuss of its safety guarantee" that a case of a 27-year-old PABC patient admitted to the Central Hospital of Cangzhou City, Hebei Province. The patient presented with a right breast mass discovered at 33 weeks of gestation, 10 days prior to admission. Outpatient bilateral breast ultrasound revealed a hypoechoic mass in the right breast (BI-RADS 4b category) and enlarged right axillary lymph nodes, with an initial diagnosis of right breast cancer. Electrosurgical equipment was used to perform a modified radical mastectomy. Prior to the procedure, the patient and her family were consulted multiple times, and they strongly expressed their desire to preserve the pregnancy. A multidisciplinary consultation involving the breast surgery, obstetrics, and anaesthesiology departments found no significant contraindications for surgery. Therefore, the procedure was conducted under general anaesthesia with continuous fetal heart monitoring.

 

In conventional surgery, procedures such as free flap dissection, total mastectomy, and axillary lymph node dissection all utilise monopolar high-frequency electrosurgical instruments. The principle of operation of monopolar high-frequency electrosurgical instruments is as follows: the high-frequency current from the electrosurgical instrument is applied to the human body via the electrosurgical pencil, producing cutting or coagulation effects. The current is conducted through the human body and returns to the electrosurgical equipment via the return negative electrode. To minimise the impact of using the high-frequency electrosurgical knife on the patient, a low-frequency cutting mode at 35 kHz and a low-frequency electrocoagulation mode at 30 kHz are employed. At the same frequency, these modes cause the least damage to both the mother and the foetus. 

 

Conventional modified radical mastectomy (MRM) for breast cancer typically does not involve the use of bipolar forceps. However, due to the specific condition of this patient, bipolar coagulation was employed during flap dissection and hemostasis, as well as in the handling of small vessels and lymphatics, effectively reducing the use of monopolar electrosurgery. The technique demonstrated reliable hemostasis, minimizing the need for ligatures.

 

Based on intraoperative data, standard MRM performed with minimal use of electrosurgical devices generally requires around 95 minutes with an average blood loss of approximately 50 ml. In contrast, the PABC (Pregnancy-Associated Breast Cancer) patient in this study underwent surgery with the same approach and extent of dissection, yet the operative time was reduced to 80 minutes and blood loss to about 30 ml. The appropriate use of electrosurgical tools clearly contributed to this improvement.

 

Follow-up at 10 days postoperatively showed good flap perfusion at the incision site, with normal color and volume of axillary drainage and no significant surgical complications.

 

ShouLiang-med’s high-frequency surgical system offers multiple cutting and coagulation modes, meeting the low-frequency energy needs required for MRM in PABC patients. This supports shorter operative times and reduced blood loss, contributing to maternal-fetal safety. In addition, ShouLiang-med’s monopolar and bipolar instruments are made with high-quality non-stick materials, further minimizing the risk of tissue adhesion during surgery.