AGISEAL A Safe and Effective Choice for Weight-loss Surgery

Since the 1950s, the medical field has been dedicated to solving the "century-old problem" of obesity. In 1952, Swedish doctor Henrikson attempted to treat obesity through extensive small bowel resection. By 1966, a doctor in the United States, inspired by the significant weight loss of patients who had undergone total gastrectomy, designed the prototype of the gastric bypass procedure. Since then, weight loss surgery has continually evolved, from open surgery to minimally invasive techniques like sleeve gastrectomy and RYGB gastric bypass, significantly improving safety and effectiveness.

 

There are various types of weight loss and metabolic surgeries, but sleeve gastrectomy has become the most widely used procedure globally due to its simplicity and lower risk of complications. By reducing stomach volume and restricting digestion and absorption, it can achieve long-term stable weight control and also improve obesity-related chronic diseases such as hypertension, diabetes, and sleep apnea. This has led to the shift of weight loss surgery from being merely a weight loss procedure to becoming a standard treatment for metabolic diseases.

 

As the number of patients undergoing these procedures continues to grow, the patient profile has also become clearer. Patients undergoing weight loss surgery typically have high demands for surgical safety and low tolerance for complications. Many guidelines emphasize the proper use of energy-based devices, as the occurrence of complications like gastric leakage is closely related to them. Since the early use of electrosurgical instruments in surgeries, devices that convert electrical energy into heat to achieve hemostasis have gradually replaced traditional cold knife cutting and suturing tools. Current mainstream devices, such as high-frequency electrosurgical knives, ultrasonic knives, and large vessel sealing devices, offer excellent hemostasis, quick cutting, high safety, and effectiveness, making them essential tools in modern surgery.

 

AGISEAL is one of these devices. It is based on the bipolar mode of high-frequency electrosurgical knives, with intelligent updates and iterations to the main unit technology, and has undergone optimization to enlarge the instrument's jaw for sealing and cutting large-diameter blood vessels (below 7mm). This significantly reduces the complex operations and time required by traditional suturing, earning it the title of "advanced bipolar." AGISEAL has shown excellent application in weight loss and metabolic surgeries and has received widespread praise from clinical experts. For example, under precise energy control, it reaches the minimum heat level, ensuring good clinical outcomes while maximizing the avoidance of burns to the gastric wall and the gastric fundus HIS angle, thereby reducing complications such as gastric leakage and gastroesophageal reflux. It meets patients' treatment needs while safeguarding their prognosis and precisely matches the patient profile.

 

Moreover, it combines safe sealing, rapid cutting, non-invasive holding, and fine dissection in one device, which means there is no need to switch surgical instruments or perform suturing and ligation when handling the stomach's greater omentum and short gastric arteries. A single SL0844 can efficiently complete the task, significantly reducing the operational time, helping to save on surgery time, and improving the operational efficiency of medical institutions and clinical departments, ultimately enhancing overall benefits.

 

In conclusion, the AGISEAL series is the undisputed choice to ensure surgical safety and improve efficiency in weight loss surgery.

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Bipolar Coagulation Forceps Enabling Precise Manipulation and Accelerated Recovery in Hemorrhoidectomy

Hemorrhoids are one of the most common anorectal diseases in clinical practice, with primary symptoms including bleeding, pain, and even prolapse, significantly impacting patients' quality of life. For patients with severe hemorrhoids, surgical excision is an effective treatment. Traditional surgery often employs monopolar electrocautery, which is widely used but associated with issues such as significant thermal damage and slow postoperative recovery. In recent years, with advancements in minimally invasive surgical techniques, bipolar coagulation forceps have been increasingly adopted in hemorrhoidectomy, demonstrating notable advantages.

 

Most medical institutions in China still commonly use monopolar electrocautery for hemorrhoidectomy. This device generates high heat through high-frequency current to achieve tissue cutting and coagulation. Although relatively simple to operate, the current must pass through the patient’s body to form a circuit, resulting in a broader thermal spread that can cause additional damage to healthy tissue around the wound edges. This leads to noticeable postoperative pain, prolonged wound healing, and a relatively higher incidence of complications such as urinary retention and incisional edema [1].

 

In contrast, bipolar coagulation forceps confine the current to a minimal area between the two tips, eliminating the need for a circuit through the body. The energy is highly concentrated, with minimal thermal diffusion. While achieving precise hemostasis, it maximally preserves surrounding healthy tissue, making it particularly suitable for the perianal region with dense vascular distribution. Clinical studies have shown that using bipolar coagulation forceps for hemorrhoidectomy significantly reduces operative time, intraoperative blood loss, postoperative pain scores, and promotes wound healing. Additionally, the incidence of complications such as postoperative edema and urinary dysfunction is significantly lower compared to traditional electrocautery [2].

 

ShouLiang-med’s independently developed bipolar coagulation forceps integrate high-precision tip design and anti-adhesive coating technology, ensuring concentrated current and minimal thermal damage. They are particularly suitable for delicate procedures such as hemorrhoidectomy. The "coagulation-dissection simultaneously" function enhances anatomical efficiency and operational smoothness, providing a clear surgical field and significantly improving surgical safety and postoperative recovery quality.

 

The application of bipolar coagulation forceps in hemorrhoidectomy offers multiple advantages, including minimal damage, rapid recovery, and fewer complications, aligning with the principles of modern minimally invasive surgery and enhanced recovery after surgery. ShouLiang-med’s bipolar coagulation forceps, with their excellent performance, are a reliable choice in the field of anorectal surgery.

 

References:

[1] Zhang P. Application analysis of procedure for prolapse and hemorrhoids (PPH) in the treatment of hemorrhoids. Chinese Journal of Medical Guide, 2016, 18(5): 440-441.

[2] Song J F. Application of bipolar coagulation forceps in hemorrhoidectomy. Journal of Clinical Medical Literature, 2019, 6(83): 73-74.

[3] Chen J Z, Xiang D Z, Geng X L, et al. Efficacy comparison of modified procedure for prolapse and hemorrhoids versus traditional surgery in the treatment of moderate-to-severe hemorrhoids. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2013, 22(16): 1759-1760.

[4] Dai H, Hu Q, Huang J T, et al. Evaluation of bipolar coagulation technology in anorectal surgery. Journal of Hunan University (Medical Sciences), 2017, 14(1): 127-129.

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LEEP Electrosurgical Excision Procedure An Efficient and Precise Treatment for Cervical Diseases

Chronic cervicitis, including cervical erosion, hypertrophy, polyps, etc., are common conditions in women of childbearing age. In some gynecological outpatient departments, the incidence can reach nearly 10%. Traditional treatment methods such as cryotherapy, laser, microwave, and medications have had some efficacy but often fail to achieve satisfactory results and have high recurrence rates. In recent years, the incidence of CIN (Cervical Intraepithelial Neoplasia) has been rising among women of reproductive age, which is a crucial stage in the progression to invasive cervical cancer. Early diagnosis and treatment can significantly reduce the incidence of cervical cancer. Some hospitals have now included cervical carcinoma in situ in the scope of LEEP electrosurgical excision.

 

LEEP electrosurgical excision has shown significant advantages in the treatment of cervical diseases. According to the clinical observation study "Clinical Observation of LEEP Electrosurgical Excision for Cervical Diseases in 276 Cases," published by Wu Shengjun and others in Chinese Journal of Maternal and Child Health Research, this technique uses a high-frequency electrosurgical knife to precisely excise the diseased tissue. The procedure causes minimal discomfort for patients, with only a small number experiencing mild lower abdominal pain or a burning sensation. The average blood loss is only 5-6 mL, and the surgery time is as short as 7.3 minutes, with no need for hospitalization, making it an outpatient procedure. Postoperative recovery is quick, with 96.4% of patients showing normal cervical morphology within 1-2 months, and the overall complication rate is low.

 

Furthermore, the LEEP procedure combines both diagnostic and therapeutic functions. The excised tissue is free of carbonization, making it suitable for pathological examination, which is especially beneficial for early intervention in CIN. Compared to traditional methods such as cryotherapy and laser, LEEP has a lower recurrence rate and can preserve the patient's fertility. It is effective for various lesions such as cervical erosion, polyps, condyloma acuminata, and submucosal fibroids, and is easy to operate with high safety. Although long-term outcomes, such as the risk of cervical canal stenosis, still require more data validation, existing research indicates that its clinical value for widespread use is significant.

 

ShouLiang-med is committed to providing safe and stable high-frequency surgical equipment and a variety of gynecological surgical instruments. Its self-developed High Frequency Generator feature multiple cutting and coagulation modes, which meet the cutting and coagulation needs of gynecological surgeries, further reducing surgery time and blood loss, thereby ensuring patient safety. The company also offers different specifications of LEEP electrodes to meet the needs of various surgical scenarios. The electrodes are made of high-quality tungsten alloy, which further reduces the risks associated with tissue adhesion and carbonization during the procedure. Shouliang Medical's instruments are recognized by clinicians for their excellent materials, good anti-adhesion properties, and precise cutting and coagulation effects. The company hopes to provide safer solutions for global patients and more efficient energy systems for medical institutions in the future.

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Understanding Optical Coherence Tomography Technology in One Article.

I. What is OCT? A Core Metaphor


Let’s understand OCT through a vivid analogy:

Imagine a fresh sandwich. A regular camera can only capture its top view (a two-dimensional photo). OCT, however, acts like a precise “optical scalpel.” It can slice the sandwich layer by layer without damage, capturing ultra-high-resolution images of each component (bread, vegetables, meat slices). These cross-sectional images are then reconstructed into a three-dimensional model.

In the eye, this “sandwich” is your retina—the light-sensitive tissue at the back of the eyeball. OCT generates cross-sectional images of the retina’s microscopic structure without any incisions or contact, achieving micrometer-level precision (1 micrometer = 0.001 millimeters)—far finer than a strand of hair!



II. How Does OCT Work?

OCT operates on a principle similar to ultrasound, but instead of sound waves, it uses near-infrared light.

  1. Emission: The device emits a safe, low-energy near-infrared light beam toward your eye.
  2. Reflection: This light passes through the eyeball and reflects back from different layers of the retina. Each tissue layer reflects light signals with distinct intensities and time delays.
  3. Analysis: The device’s core interferometer precisely measures the differences between these reflected signals and the reference light (“interference” phenomenon).
  4. Imaging: A computer analyzes and processes the countless captured light signal points, instantly constructing detailed 2D or 3D images.

    III. What Can OCT Detect? Which Eye Conditions Does It Diagnose?
    OCT is a powerful tool for examining the macula (the central part of the retina responsible for sharpest vision). With it, doctors can:
  5. Precisely measure thickness: Determine whether the retina has thickened (edema, hemorrhage) or thinned (atrophy).
  6. Identify minute lesions: Detect fluid accumulation, abnormal membranes, and microbleeds invisible to the naked eye.
  7. Monitor disease progression dynamically: Evaluate treatment efficacy and guide subsequent therapeutic decisions.

    It is primarily applied in the diagnosis and management of these major blinding eye diseases:
  8. Age-related macular degeneration (AMD)

    Wet AMD: OCT clearly visualizes abnormal subretinal vessels and fluid accumulation, serving as the gold standard for diagnosis and determining the need for intravitreal injections.

    Dry AMD: OCT monitors for macular thinning (geographic atrophy) and the deposition of drusen.
  9. Diabetic Retinopathy & Diabetic Macular Edema (DME)

    OCT is the most sensitive tool for detecting DME (intraretinal fluid accumulation), precisely guiding laser or anti-VEGF drug injection treatments while objectively evaluating their efficacy.
  10. Glaucoma

    OCT accurately measures the thickness of the retinal nerve fiber layer (RNFL). Glaucoma causes the RNFL to gradually thin like the growth rings of a tree. OCT can detect these changes early, before visual field defects occur, enabling early diagnosis, timely treatment, and lifelong follow-up for glaucoma.
  11. Vitreoretinal Interface Diseases

    Such as epiretinal membrane (a membrane growing over the retina’s surface, causing distorted vision) and macular hole (a “hole” forming in the center of the macula). OCT clearly displays the morphology and staging of lesions, serving as a key basis for determining surgical necessity.

    IV. What is the OCT examination experience like?
  12. Preparation: Typically requires no special preparation. Sometimes dilating eye drops are administered to enlarge the pupil for clearer imaging, resulting in light sensitivity and blurred near vision for several hours afterward.
  13. Procedure: Simply rest your chin and forehead on the instrument’s support to keep your head steady. Focus on the fixation point inside the device (possibly a flashing cursor). The device does not touch your eyes.
  14. Duration: Scanning each eye usually takes only a few minutes.
  15. Safety: OCT uses near-infrared light. It is radiation-free, non-invasive, and has no known side effects. It is very safe and can be repeated frequently.

    V. Cutting-Edge Technology: Enhanced OCT
    OCT technology continues to evolve:
  16. OCT Angiography (OCTA): This is a revolutionary advancement. Without requiring contrast agent injections, it non-invasively reveals the intricate retinal vascular network, greatly facilitating the diagnosis of vascular diseases.
  17. Wider, Deeper, Faster: Scanning coverage is broader, penetration is deeper, speed is faster, and image quality is higher.

    3. Artificial Intelligence (AI): AI algorithms are being applied to automatically analyze OCT images, assisting physicians in rapid disease screening and diagnosis. This holds immense potential for future application in large-scale health screenings.


    Also welcome to contact us, we are ZD Medical Inc.
    Tel : +86-187 9586 9515
    Email : sales@zd-med.com
    Whatsapp/Mobile : +86-187 9586 9515

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What is the relationship between the New Vein Finder and pediatric emergency care?

Core Connection: Addressing the Most Challenging Clinical Scenarios in Pediatric Emergency Care

Pediatric emergency settings represent one of the most valuable applications for venous imaging devices. This connection is primarily manifested in addressing the following core challenges:


1. Patient Specificity: Difficulties in Establishing Venous Access

Physiological Factors: Infants and children possess inherently small, fragile blood vessels and relatively thick subcutaneous fat layers, making vessels invisible to the naked eye and difficult to palpate.

Emotional Factors: Young patients often experience fear, crying, and non-compliance, causing vasoconstriction and further complicating puncture attempts.

Dehydration/Critical Illness: In emergency settings, dehydrated, shock-affected, or hypotensive children exhibit collapsed vessels, making traditional localization nearly impossible.


2. Environmental Specificity: High Pressure and Urgency

Time Pressure: In critical situations (e.g., status epilepticus, severe dehydration, sepsis), rapidly establishing an IV line for medication administration or fluid infusion is vital for saving lives. Each failed attempt delays treatment.

Compounding Stress: A child's distress and parental anxiety create immense psychological pressure on healthcare providers, potentially leading to technical errors and creating a vicious cycle: “The more unsuccessful attempts, the greater the tension; the greater the tension, the fewer successful attempts.”

new vein imaging device

How does the new vein imaging device transform pediatric emergency care?

This innovative technology uses near-infrared light to project real-time images of subcutaneous veins directly onto the skin surface, clearly revealing vessel location, trajectory, and branching patterns.

Its specific value in pediatric emergencies includes:


1. Significantly increases first-attempt success rates

This is the most critical metric. Studies show vein imaging devices can boost first-attempt success rates in pediatric patients by 20% to 50% or more.

Significance: Reduces patient distress, shortens access establishment time, and secures a valuable window for critical interventions.


2. Reduces overall puncture attempts

Average attempts decrease from 3-4 to 1-2, or even one successful attempt.

Significance:

- Minimizes trauma for children: Prevents them from becoming “needle pads,” reducing physical and psychological harm.

- Alleviates parental anxiety: Significantly boosts parents' trust in the medical team.

- Protects healthcare providers: Lowers work frustration and enhances job satisfaction.


3. Provides solutions for “difficult vein” patients

For obese children, those with darker skin tones, severe dehydration, or multiple chemotherapy treatments, vein imaging devices are nearly the only non-invasive, rapid tool for locating veins.


4. Optimizing Workflow and Enhancing Emergency Department Efficiency

Reduces the need to call senior nurses or anesthesiologists for central venous catheterization due to repeated puncture attempts.

Enables healthcare providers to treat more patients faster, alleviating emergency department congestion.


5. As a Communication and Reassurance Tool

For patients: Project images onto their hands or toys, turning the process into a “game” to distract and reduce fear.

For parents: Visually demonstrate vein locations, helping them understand the procedure's difficulty and necessity. This transforms them from bystanders into “allies,” strengthening communication and trust.


Also welcome to contact us, we are ZD Medical Inc.
Tel : +86-187 9586 9515
Email : sales@zd-med.com
Whatsapp/Mobile : +86-187 9586 9515

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What opportunities does vein finder have in emerging markets?

1. Regional Market Opportunities: Developing Countries and Primary Healthcare


Widespread availability of primary healthcare facilities

Pain points: Community hospitals and clinics in developing countries (such as India, Southeast Asia, and Africa) lack skilled nurses, resulting in high rates of failed intravenous punctures finder.

Opportunity: Promote low-cost portable devices (e.g., domestically produced models under $4,000) in conjunction with government healthcare upgrade programs.

Vaccination and Public Health

Demand: Global vaccination coverage is increasing, but vascular localization is challenging for children in remote areas.

Solution: Collaborate with the United Nations Children’s Fund (UNICEF) to develop durable, battery-powered models suitable for high-temperature and high-humidity environments.



II. Application Scenario Expansion: Non-Traditional Medical Fields

Aesthetic Medicine and Minimally Invasive Treatments

Applications:

Precise marking of vascular pathways before varicose vein treatment.

Avoiding dangerous veins (such as the “triangle area” of the nose) during hyaluronic acid injections.

Market: The global aesthetic medicine market grows by over 10% annually, with China projected to reach 300 billion yuan by 2025. Devices can be bundled for sale to private aesthetic medicine institutions.

Veterinary Market

Demand: The rise of pet healthcare, but animal vessels (e.g., cats, exotic pets) are finer and covered by fur.

Innovation: Adjusting infrared wavelengths to suit animal skin characteristics (e.g., dog vessels absorb 850nm more strongly).

Emergency and Disaster Response

Scenario: Rapidly establishing venous access in harsh environments such as battlefields or earthquakes.

Product Direction: Earthquake-resistant and dust-proof design.



III. Opportunities Driven by Technological Innovation

AI + Augmented Reality (AR)

Function:

Real-time prediction of blood vessel depth and direction.

Combined with smart glasses to achieve “hands-free operation” (suitable for sterile operating room environments).

Barriers: Need to overcome algorithm adaptability for dark-skinned or obese patients.

Multi-functional Integrated Devices

Direction:

Venous imaging + ultrasound.

Combined with hemoglobin monitoring (suitable for dialysis centers).

Contactless Technology

Trend:

Thermal imaging + AI analysis of blood flow abnormalities (early screening for venous thrombosis).



IV. Business Model Innovation

Leasing and Subscription Model

Model:

Hospitals pay per puncture (e.g., $1–2 per puncture), lowering the procurement threshold.

Device manufacturers generate ongoing revenue through consumables (e.g., disinfectant sleeves).

Lower-tier market channels





V. Policy and Capital Trends

Policy Benefits

China’s 14th Five-Year Plan for medical equipment explicitly supports imaging equipment for grassroots healthcare facilities.

The FDA’s 2023 regulations simplify the approval process for portable imaging devices.

Investment Hotspots

Startup directions:

Focus on niche scenarios (e.g., VeinTech’s pediatric-specific devices).

Wearable devices (ring-shaped imaging devices have attracted attention from Silicon Valley venture capitalists).


Also welcome to contact us, we are ZD Medical Inc.
Tel : +86-187 9586 9515
Email : sales@zd-med.com
Whatsapp/Mobile : +86-187 9586 9515


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Crepe Paper for Sterile Safety Choosing the Right Medical Surgical Paper & Sterilization Wrapping Paper

Crepe paper isn’t just for crafts — in healthcare settings, high-quality Crepe Paper plays a vital role in protecting instruments and patients. From barrier performance to flexibility, modern creped materials deliver reliable breathability and tear resistance that make them ideal for surgical trays, instrument wraps, and packaging where sterility must be maintained without sacrificing handling convenience.




Hospitals and clinics increasingly prefer purpose-made Medical Surgical Paper because it balances microbial barrier properties with ease of use. Compared with plain non-woven sheets, specialty crepe constructions conform better around irregular instruments and give staff confident handling during sterilization cycles. When a wrap must pass autoclave or low-temperature sterilization while keeping contents sterile until point-of-use, choosing the right **Sterilization Wrapping Paper** directly affects instrument safety and workflow efficiency.




When evaluating suppliers look beyond paper weight and look for consistent crepe formation, controlled air permeability, and strong seam/edge performance — all features that reduce pinholes and maintain sterilization integrity. Practical considerations such as customizable roll widths, printed indicators, and compatibility with different sterilization methods help you match material to your facility’s protocols. Reliable sampling and clear technical data sheets speed adoption and reduce trial-and-error in procurement.




With more than 20 years as a factory serving global markets, Telijie combines proven product quality with service excellence: rapid sampling, flexible minimum orders, multilingual customer support, and tailored packaging and logistics to meet international delivery timelines. Beyond the material benefits of our Crepe Paper, Medical Surgical Paper, and **Sterilization Wrapping Paper**, Telijie offers hands-on technical guidance, responsive after-sales support, and the supply-chain consistency healthcare providers need—making Telijie the partner hospitals trust.

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Disposable Apron Buying Guide Why Dental & Paper Aprons Matter for Everyday Hygiene

In environments where cleanliness and quick turnover matter, a reliable Disposable Apron is no longer optional — it’s essential. Whether you’re running a busy dental clinic, a food-prep station, or a light-industrial line, the right apron protects staff and strengthens your hygiene protocols without adding laundering costs or storage hassles.




Disposable aprons come in many forms to fit different needs. A Dental Apron is designed for splash protection, patient comfort and easy disposal after each procedure; lightweight but effective barriers reduce cross-contamination risk. For lightweight, single-use protection in salons, catering or quick medical checks, a Paper Apron offers an economical, biodegradable option that still delivers a clean-looking, professional presentation. Choosing the correct material and size ensures staff comfort while maintaining practical protection and reducing waste management burdens.




Beyond material choice, practical benefits include rapid restocking, consistent single-use hygiene, and simplified compliance for busy teams. Many businesses prefer disposable options because they eliminate laundry cycles, lower infection risk, and free up staff time for care rather than cleaning. When comparing alternatives, consider thickness, tie/neck style, and compatibility with other PPE so the Disposable Apron integrates seamlessly into your workflow.




For customers who require reliable supply and thoughtful service, Telijie stands apart. With over 20 years as a manufacturing partner serving global markets, Telijie combines factory-direct pricing with attentive OEM support, fast sample turnaround, and strict quality control throughout production. We help customers choose the right Disposable Apron, Dental Apron, or Paper Apron for their application, offer flexible customization (sizes, printing, packaging), and manage logistics to ensure steady supply. If you value decades of production experience plus responsive after-sales service, Telijie is built to deliver.

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Soft, Hygienic, Reliable Why Your Clinic Needs an Examination Couch Paper Roll

Clean, comfortable patient care begins with the small details — like the sheet that lies between patient and couch. For clinics, physiotherapy centers, and beauty salons that value hygiene and professionalism, the right paper roll makes a measurable difference to patient confidence and infection control. A high-quality Examination Couch Paper Roll protects surfaces, reduces laundering costs, and makes turnover between patients faster and neater.



Modern facilities need more than just a roll of paper; they need a dependable solution that performs under real-world pressure. Our Disposable Paper Bedsheet Roll options are designed for tear resistance, consistent unwind, and a smooth finish that won’t irritate skin. Whether you run a busy family practice or a specialist clinic, choosing the correct weight and width means fewer interruptions and a better experience for both staff and patients.



For medical settings where compliance and convenience matter most, Medical Couch Rolls combine sanitary performance with cost efficiency. Look for rolls manufactured under strict quality controls, available in perforated and non-perforated formats, and compatible with standard couch dispensers. These rolls simplify inventory management while supporting infection control protocols — a small change that yields big operational benefits.



As a factory with over 20 years’ experience serving the global market, Telijie knows the standards clinics expect. Beyond durable products, Telijie offers flexible OEM options, low minimum order quantities for trials, rapid production lead times, full quality inspection, and dependable international logistics. Our dedicated customer support helps with product selection, custom printing, and after-sales service — all designed to make switching to better Examination Couch Paper Roll and Medical Couch Rolls seamless for your practice. Choose Telijie for trusted products and service that keep your clinic running smoothly.

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Test Sooner, Act Faster – Enhance Sepsis Care with Poclight Diagnostics

1. The Global Burden of Sepsis

 

Sepsis is a life-threatening condition caused by the body’s extreme response to infection.

From data published in 2020, globally, over 49 million people are affected each year, with approximately 11 million deaths, representing 20% of all global deaths (Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the Global Burden of Disease Study. Lancet. 2020 Jan 18).

 

sepsis worldwide

 

Sepsis affects people globally, but incidence and mortality are highest in lower-middle-income countries (LMICs). In high-income countries, the average hospital cost per sepsis patient exceeds US$32,000.

 

Understanding the Risk

Anyone can develop an infection that leads to sepsis, but certain factors increase susceptibility. Older adults, infants (40% of all cases), pregnant women, and patients with pre-existing conditions—such as chronic kidney disease, liver disease, cancer, or heart failure—face higher risk.

 

sepsis in children

early diagnosis of sepsis

 

Socioeconomic factors, access to healthcare, and living conditions also play a role, particularly in low- and middle-income countries where infections may be more prevalent and timely medical care is harder to access.

● High-risk populations: older adults, infants (half of all cases), pregnant women

● Pre-existing conditions: chronic kidney disease, liver disease, cancer, heart failure

● Socioeconomic & environmental factors: limited healthcare access, overcrowded living, poor sanitation

 

2. The Role of Biomarkers in Sepsis Diagnosis

 

Inflammatory biomarkers are measurable indicators of the body’s immune response to infection. In sepsis, key inflammatory biomarkers may include the following:

sepsis biomarkers

Sepsis, septic shock, and sepsis-associated encephalopathy biomarkers. (Barichello, T., Generoso, J.S., Singer, M. et al. Biomarkers for sepsis: more than just fever and leukocytosis—a narrative review. Crit Care 26, 14 (2022))

 

kinetics of key inflammation markers

Biomarker Kinetics After Bacterial Infection

 

Clinical benefits of monitoring these biomarkers:

● Early detection of sepsis and assessment of severity

● Informed decisions on initiating, adjusting, or discontinuing antimicrobial therapy

● Support antimicrobial stewardship (AMS): Reduced unnecessary antibiotic exposure without increasing mortality

● Real-time monitoring of treatment effectiveness alongside pathogen identification and antibiotic susceptibility testing

 

3. Poclight’s Solution: Speed, Precision, and Accessibility

 

Poclight’s C5000 dry chemiluminescence immunoassay system offers a reliable approach to testing a panel of inflammatory and sepsis-related biomarkers, including PCT, CRP, IL-6, and HBP.

Category

Test

Sample types

Assay duration

Sample volume

Cut-Off value of Sepsis

Measuring range

INFLAMMATION

CRP test kit

Serum/Plasma

/Whole Blood

3min

5 μL

>100 mg/L

>10 mg/L neonatal

(low specificity, cannot diagnose sepsis alone)

0.5~320 mg/L

IL-6 test kit

Serum/Plasma

15min

100 μL

>250 pg/mL possible sepsis

1.5~5000 pg/mL

PCT test kit

Serum/Plasma

5min

200 μL

>0.5 ng/mL

high risk of sepsis

0.02~100 ng/mL

HBP test kit

Plasma

5min

50 μL

>28.1 ng/mL

5.9~300 ng/mL

Note: The reference values provided for each biomarker are for guidance only. Final clinical diagnosis should not rely on a single parameter, but instead be based on a comprehensive assessment that combines multiple biomarkers, diagnostic tools, and clinical evaluation.

 

1)  High Sensitivity & Specificity

Fully homogeneous chemiluminescence technology enables precise detection of small-molecule hormones and inflammatory markers, minimizing false results.

2)  Single-Test Freeze-Dried Reagents

Each assay comes as a single-dose, freeze-dried reagent that is stable at room temperature for up to 18 months, simplifying storage and transport—ideal for hospitals, primary care clinics, and remote settings.

Poclight freeze-dried reagents

 

3)  Rapid Turnaround

Test results in as fast as 3 minutes, enabling fast clinical decisions in critical situations.

4)  Cost-Effective: Low per-test cost allows frequent testing, saving healthcare budgets.

5)  Versatile and User-Friendly

Compact, simplified instruments make the system suitable for diverse clinical environments, from GP, clinics, to labs.

C5000 analyzer

 

By enabling early and accurate sepsis detection, Poclight diagnostics support clinicians in providing timely treatment while avoiding unnecessary broad-spectrum antibiotic use.

 

Detect sepsis early, respond rapidly, and save lives - Care in Time with Poclight

Get in touch with our specialists to get started and discover how we can help.

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