A Guide to Choosing the Right CLIA Kit

Chemiluminescent immunoassay (CLIA) kits have become indispensable tools in modern clinical laboratories, thanks to their high sensitivity, specificity, and automation potential. Whether you're screening for infectious diseases or monitoring tumor markers, understanding how these kits work and how to choose the right one is critical for reliable results and efficient diagnostics.

1. Overview of Chemiluminescent Immunoassay Kits

Chemiluminescent immunoassay kits detect specific antigens or antibodies based on a luminescent chemical reaction. Here’s how it works: an antigen-antibody binding event is coupled with a chemiluminescent substrate that emits light when catalyzed by an enzyme. The emitted light is then measured using a luminometer, with the intensity proportional to the concentration of the target analyte.

Application Areas:

- **Clinical Diagnostics**: thyroid function tests, cardiac markers.

- **Infectious Disease Testing**: CRP, SAA, IL-6, PCT, KL-6, HBP, COVID-19 antibody/antigen detection.

- **Tumor Marker Detection**: PSA, AFP, CA125, and more.

- **Cardiac**: D-dimer, BNP, NT-proBNP, CK-MB, Myo, hs-cTnT, RF detection.

- *Fertility Tests*: beta-hCG, Prolactin, Prog, Cortisol, FSH, AMH, Testosterone, LH, Estradiol

Immunoassay Test-Kits

2. Selection Criteria and Considerations

### Sensitivity and Specificity:

The reliability of diagnostic results hinges on sensitivity (true positive rate) and specificity (true negative rate). High sensitivity ensures even trace amounts of biomarkers are detected, while high specificity reduces false positives. Always check:

- Sensitivity % (ideally >95%)

- Specificity % (ideally >95%)

### Detection Range:

Different kits are tailored for specific analytes. Make sure to align your selection with your lab’s testing focus:

- **Hormones**: TSH, LH, hCG

- **Viral Markers**: HBsAg, HCV Ab

Verify that the kit covers the necessary linear detection range for your sample type and concentration needs.

3. Product Quality and Certification

Quality assurance is non-negotiable in clinical diagnostics. Look for kits that carry:

- CE Mark (Europe)

- FDA Approval or EUA (U.S.)

- ISO 13485 certification for manufacturing processes

Additionally, consider the manufacturer's:

- **Reputation**: Years in the market, reviews, known partnerships

- **Production Standards**: GMP compliance, QC systems

- **Batch-to-batch consistency**: Crucial for longitudinal studies or repeated testing

4. Ease of Use

Modern CLIA kits are often designed with automation in mind, but workflow simplicity still varies. Evaluate:

- **Number of steps**: Manual vs. automated workflow

- **Sample preparation**: Plasma, serum, whole blood compatibility

- **Training Requirements**: Is the kit suitable for labs with limited technical personnel?

A good kit should offer intuitive instructions and come with technical support when needed.

 5. Cost and Value for Money

CLIA kits vary in price depending on:

- Target analyte

- Brand reputation

- Certification level

While budget is important, avoid choosing solely based on price. Instead, assess:

- Cost per test

- Shelf life and storage conditions

- Bundled services or equipment availability

One of Poclight's strongest advantages is that our analyzer offer a simple one-step operation, making it highly user-friendly. Additionally, our kits eliminate the need for washing or separation processes, which not only saves time but also reduces the potential for errors. With minimal maintenance requirements, these kits are designed to facilitate smooth workflows, ensuring that even labs with limited technical personnel can operate them effectively.

 

Another strong advantage is the reagents is Lyophilized Beads NO COLD CHAIN NEEDED, NO refrigerators needed, with long shelf-life.

This guide provides a comprehensive overview to help you choose the right chemiluminescent immunoassay kits for your laboratory needs.

Top

Anemia Test (CLIA) Kits——Folic acid, vitamin B12, ferritin (CLIA) kit

Anemia is a common health issue that can arise from various deficiencies, particularly in folate, vitamin B12, and serum ferritin. Poclight's anemia testing kits (CLIA) utilizes homogeneous chemiluminescent immunoassay to provide a thorough assessment of these key serum markers. This holistic approach aids clinicians in accurately diagnosing the underlying causes and types of anemia, facilitating early intervention and effective treatment for patients.

Traditional methods for anemia testing often have significant drawbacks. Many conventional techniques rely on complex procedures that can introduce variability and require extensive sample handling. These methods may also lack the sensitivity needed to detect subtle deficiencies, leading to potential misdiagnoses and delayed treatment. As a result, there's a pressing need for more reliable and streamlined testing solutions.

Poclight‘s anemia testing kits addresses these challenges with several distinct advantages. The innovative use of graphene oxide eliminates the need for magnetic beads, simplifying the process by removing separation and washing steps. This not only streamlines the workflow but also enhances the overall performance of the assay, increasing sensitivity by one to two orders of magnitude.

Moreover, Poclight's kits offers exceptional cost-effectiveness. The Lyophilized Beads reagent is designed for individual packaging, eliminating the need for refrigeration and significantly reducing the risks associated with transportation and storage. The compact design of our analyzer can be widely used in multiple scenarios, making them ideal for hospitals, clinics, and laboratories.

Human Vitamin B12 CLIA Kits

Poclight's anemia testing kits (CLIA), including Active-B12 (AB12) test kits (Homogeneous Chemiluminescence Immunoassay), Folate test kits (Homogeneous Chemiluminescence Immunoassay)stands out as a groundbreaking solution in the field of diagnostic testing. By combining advanced technology with practical design, we empower healthcare providers to deliver timely and accurate anemia diagnoses, ultimately improving patient outcomes. 

 

Top

Exciting Announcement Join Us at Hospitalar 2025 in Brazil!

We are thrilled to announce that Poclight will be showcasing our innovative instruments and reagents at the Hospitalar 2025 Medical Equipment Exhibition in Brazil this May. We invite both new and returning customers to visit our booth for an exclusive look at our cutting-edge products.

 

Our featured testing kit utilizes the unique properties of graphene oxide, eliminating the need for magnetic beads and simplifying the process by removing complex separation and washing steps. This results in a more efficient workflow and enhances the overall performance of the assay.

 

One of the standout benefits of Poclight's technology is the significant increase in sensitivity—by one to two orders of magnitude—allowing for more accurate and reliable results. This streamlined process not only improves performance but also makes it easier for healthcare professionals to obtain critical data.

 

Additionally, our kits offers exceptional cost-effectiveness. With low testing costs, individual packing Lyophilized Beads reagents that don’t require refrigeration, we greatly reduce the risks associated with transportation and storage. The compact and user-friendly design of our instruments ensures versatility across various application scenarios.

 

Don’t miss this opportunity to explore Poclight's innovative solutions and discuss how we can support your needs. We look forward to welcoming you at Hospitalar 2025!

Top

Enhancing Medical Hygiene with High-Performance Medical Wiping Paper

In the fast-paced and highly regulated environment of medical facilities, every tool and supply must meet stringent performance standards — and that includes wiping materials. Medical wiping paper plays a vital role in maintaining a sterile, clean workspace, whether in operating rooms, labs, or general patient care. Its functionality goes beyond simple cleanup; it ensures safety, efficiency, and compliance.


Medical Paper Sheet


White Surgical wiping paper

What sets this Medical wiping paper apart is its innovative composition. Made from pure wood pulp combined with reinforced grid lines, this paper achieves the perfect balance of strength and softness. It's highly absorbent, both for oil and water, and boasts excellent wet strength — meaning it doesn’t tear easily, even when soaked. Plus, it's environmentally friendly and fully biodegradable, a growing concern for hospitals seeking sustainable solutions.


Sterile Medical Paper Towel


Designed with surgical environments in mind, our Surgical wiping paper offers exceptional lint-free performance. This ensures that no particles are left behind on surgical tools or surfaces, maintaining the high standard of cleanliness required in operating rooms. The strong fiber network resists shedding, making it a reliable choice for delicate procedures and equipment preparation.


Sterile wiping paper


Sterile Dry Wipes

When sterilization is non-negotiable, the Sterilization wiping paper steps in. Ideal for use before and after autoclave procedures, this variant supports effective disinfection protocols without compromising integrity. Its superior resistance to disintegration under moisture and pressure makes it an essential component in infection control processes.


Disposable Dry Wipes


Customers choose Medical wiping paper not only for its material advantages but also because of the trusted service behind it. Telijie provides tailored support to meet the diverse needs of healthcare providers, from prompt delivery schedules to responsive customer service. Whether you're managing a small clinic or a large hospital network, Telijie ensures that product quality is matched by service excellence.


Sterile Paper Towels

Explore how our range of Medical wiping paper, Surgical wiping paper, and Sterilization wiping paper can upgrade your facility’s hygiene standards while aligning with your environmental values — backed by Telijie, a brand committed to quality, reliability, and care.

Top

The Ideal Choice for Cleanroom and Surgical Environments Medical Wiping Paper

In medical, surgical, and laboratory settings, maintaining cleanliness and hygiene is not just a requirement—it’s a necessity. One of the unsung heroes of these environments is high-quality Medical wiping paper. Designed to meet stringent hygiene standards, this essential product is specifically crafted for high-performance cleaning and wiping tasks in professional medical applications.



What sets Medical wiping paper apart is its unique composition. Made from pure wood pulp combined with a scrim mesh, this material offers a perfect balance between strength and softness. The result is a scrim reinforced hand paper that boasts exceptional durability, superior absorbency for both oil and water, and remarkable resistance to tearing even when wet. It’s lint-free, ensuring that no fibers are left behind—critical in any surgical or cleanroom environment.



Healthcare professionals consistently rely on Surgical wiping paper for its high absorbency and strength. Whether used to clean instruments, wipe down surfaces, or manage fluids during procedures, this product supports a more sterile and efficient workspace. Its biodegradable nature also means that hospitals and clinics can uphold their environmental commitments without compromising on quality or performance.



In addition to its environmental benefits and robust material design, what truly makes Medical wiping paper a standout choice is the level of service and consistency provided by Telijie. As a trusted name in medical-grade paper solutions, Telijie goes beyond just delivering excellent products. With reliable logistics, responsive customer support, and a commitment to quality assurance, Telijie ensures that every client receives not only superior Medical wiping paper, but also peace of mind.



When it comes to choosing the right Surgical wiping paper or scrim reinforced hand paper for demanding medical environments, professionals turn to Telijie—a name that combines product excellence with dependable service.

Top

Effects of Adenoid Low-Temperature Plasma Radiofrequency Ablation on Children with Snoring

Obstructive Sleep Apnea-Hypopnea Syndrome (OSAHS) is very common in pediatric clinical practice. OSAHS is characterized by breath-holding and snoring. If not treated appropriately, it can have a direct impact on the body’s development and may even endanger the respiratory system. Therefore, providing scientific treatment measures to improve the child's ventilation function is of great importance[1].

 

Research[2]has found that TNF-a is an important inflammatory cytokine, playing a key role in the occurrence and development of various diseases. IL-6 is a pro-inflammatory cytokine that shows a significant increase in many inflammatory diseases, while IL-10 is an anti-inflammatory cytokine that can control the inflammatory response.

 

Adenoid low-temperature plasma radiofrequency ablation (ELTPRA) has shown significant effects in reducing the levels of inflammatory factors in children with OSAHS. This method not only shortens the time for symptom relief and hospital stay but also effectively reduces intraoperative blood loss, thus accelerating the recovery process.

 

The reason for this effect lies in the fact that ELTPRA is a minimally invasive technique. Using low-temperature plasma radiofrequency as the core technological principle, it applies appropriate ion temperatures to ablate the diseased tissue, thereby improving the child’s ventilation function. Additionally, by utilizing endoscopic technology, the diseased tissue can be magnified and displayed more clearly, ensuring better surgical safety. This ultimately shortens the operation time and reduces bleeding.

 

Additionally, treatment via the plasma system can help reduce systemic inflammatory responses in pediatric patients. This is attributed to the technology's precise techniques, which minimize damage to surrounding tissues, thereby lowering inflammatory factor levels. Meanwhile, ELTPRA is a technique that combines hemostasis, perforation, cutting and irrigation, carried out with a multi-angle high-definition nasal endoscopy, which helps the surgeons to carry out precise operations, reduce intraoperative bleeding, and avoid harm to adjacent normal tissues, ultimately shortening hospitalization time [1]

 

Study[3] found that ELTPRA, with its precision and standardised intervention on

the turbinate, tongue base and soft palate, helps to maximise the preservation of nasal mucosal function, reduces the adverse effects on ventilation and improves sleep quality. 

 

 

References: 

[1] Chen X. Effects of adenoid low-temperature plasma radiofrequency ablation on AHI and ODI in children with snoring disease. Guizhou Medical Journal, 2025;49(03):407-409.  

[2] Liu H, Li S, Xin Y, et al. Clinical characteristics of sleep quality and cognitive function in patients with chronic insomnia co-morbid OSAHS and their correlation with serum NLRP3 inflammatory vesicles,IL-1β,and IL-18 levels. China Journal of Modern Medicine. 2023;33(13):78-87.  

[3] Xu M, Jin X, Sun Y, et al. Sonological analysis of voice training on the recovery of voice function after plasma radiofrequency ablation of early-stage glottic carcinoma. *Chinese Journal of Otorhinolaryngology-Skull Base Surgery. 2022;28(02):95-98.  

Top

What Are the Advantages of Energy-Based Surgical Devices?

Tissue cutting and hemostasis have always been at the heart of surgical progress. Since the 1920s, when surgeons first began using electric current to treat tissue, energy-based surgical devices have become essential tools in modern operating rooms. These instruments are widely used for cutting, dissecting, coagulating, and sealing tissue across various specialties, including thoracic surgery, general surgery, gynecology, and urology.

 

Today, the development of energy-based surgical devices is increasingly driven by intelligent technologies—such as tissue recognition, speed control for cutting and sealing, temperature regulation, and optimized user interfaces. Core innovations like smart temperature control, frequency tracking, digital impedance matching, and adaptive tissue response are powered by sophisticated algorithms. These features directly impact surgical outcomes by enhancing cutting efficiency, hemostatic performance, and operational stability.

 

As a continuous explorer in the field of energy surgical instruments, ShouLiang-med's AGISEAL series stands out with its cutting-edge technologies. Its intelligent temperature control system can accurately adjust the surgical temperature to minimise thermal damage to the surrounding tissues; the frequency tracking function can adjust the energy output in real time according to the characteristics of the tissues to ensure the precision of cutting and coagulation; The digital impedance matching mechanism can quickly adapt to the changes in the tissues to ensure the high efficiency and stability of the energy transmission; the tissue adaptive cutting technology can intelligently identify tissue type and thickness, and automatically optimize cutting force and speed. 

 

Additionally, AGISEAL features user-friendly operation and enhanced safety, providing surgeons with efficient, secure, and stable surgical solutions. This innovative series has become a trusted surgical instrument among clinical experts worldwide.

Top

Custom Plastic Bags with a Logo Elevate Your Packaging Game with AI 650 Specimen Bags

In today’s competitive market, your packaging isn’t just a container—it’s a branding opportunity. Custom plastic bags with your logo not only protect your products but also turn every delivery into a chance to reinforce your brand identity. At [Your Company Name], we specialize in high-performance, customizable solutions like the AI 650 Specimen Bag, designed to meet both practical and promotional needs. Here’s why custom branding and the AI 650 are game-changers for your business.

 

Why Choose Custom Plastic Bags with a Logo?

  • Brand Visibility

         Every time your product is handled, transported, or stored, your logo becomes a silent ambassador. Whether it’s for medical specimens, industrial parts, or retail goods, branded bags leave a lasting impression.

  • Professionalism & Trust

       Customized packaging signals attention to detail and reliability. For industries like healthcare or laboratories (where the AI 650 Specimen Bag excels), this builds credibility with clients and end-users.

  • Versatility

        From tamper-evident seals to anti-static properties, custom bags can be tailored to your niche requirements.

 

Meet the AI 650 Specimen Bag: Durability Meets Customization

The AI 650 Specimen Bag is engineered for demanding environments, making it ideal for medical, laboratory, and industrial applications. Here’s what sets it apart:

  • Premium Material: Made from puncture-resistant, leak-proof polyethylene to protect sensitive contents.
  • Secure Closure: Self-sealing adhesive strip ensures tamper-proof security.
  • Custom Branding Options: Print your logo, handling instructions, or compliance labels in high-resolution color.
  • Compliance Ready: Meets OSHA and biohazard safety standards for medical use.

Whether you’re shipping lab samples, pharmaceutical products, or industrial components, the AI 650 combines functionality with brand enhancement.

 

How to Design Your Custom AI 650 Bags?

  1. Logo & Graphics: Provide your vector logo for crisp, fade-resistant printing.
  2. Text & Labels: Add essential info like “Handle with Care,” “Biohazard,” or contact details.
  3. Color Matching: Choose from Pantone colors to align with your brand guidelines.

 

Case Study: Boosting Brand Recognition in Healthcare

A regional laboratory switched to custom-branded AI 650 Specimen Bags and saw:

  • 30% faster inventory identification
  • Improved client trust with professional, standardized packaging
  • Reduced cross-contamination risks with clear labeling

 

Why Partner with Advance International Corp?

Fast Turnaround: Prototypes in 7 days, bulk orders shipped globally in 2-3 weeks.

Competitive Pricing: No hidden fees—custom branding at wholesale rates.

Dedicated Support: Our team guides you through design, compliance, and logistics.

 

Ready to Transform Your Packaging?

Elevate your brand with custom AI 650 Specimen Bags that deliver safety, compliance, and visibility.

📞 Contact us today: +8619109699110

📧 Email:  sales@95kpabags.com

🌐 Explore options: http://www.95kpa-bags.com/

Top

Nucleic Acid Vaccine Technology Biomedical Research Series

Unlike traditional vaccines that rely on inactivated pathogens or recombinant proteins, nucleic acid vaccines deliver DNA or RNA molecules encoding antigens to directly synthesize target proteins in host cells and activate precise immune responses.

This path has shown great potential in the COVID-19 pandemic - it took only 11 months from sequence design to approval for mRNA vaccines, setting a new record in the history of drug development. It not only verifies the rapid response advantage of nucleic acid technology, but also promotes a profound reconstruction of the global biomedical industry.

However, despite the advantages of high efficiency, rapidity, and safety, this technology still faces challenges such as delivery efficiency, reliance on low-temperature storage, and long-term safety to be verified. This article aims to sort out nucleic acid vaccine technology, including concepts, principles, challenges, and future trends, in order to increase readers' understanding and promote industrial development.

 

Industry Overview               

Nucleic acid vaccines, also known as gene vaccines, are to directly introduce exogenous genes encoding a certain antigen protein into animal cells, synthesize antigen proteins with the help of the host cell expression system, and then induce the host to produce an immune response to the antigen protein to achieve the purpose of preventing and treating diseases.

According to the main components, nucleic acid vaccines are divided into DNA vaccines and mRNA vaccines. Nucleic acid vaccines have changed the traditional vaccine model of relying on pathogen treatment. Starting from the genetic level, they have opened up a new path to use human cells to produce immune stimulants, bringing new ideas and methods to disease prevention and treatment.

 

Compared with traditional vaccines, nucleic acid vaccines have many advantages:

  • First, the protective efficacy is enhanced. Nucleic acid vaccines can stimulate cellular immunity and humoral immunity at the same time. Compared with traditional vaccines that often trigger a single immune response, such as inactivated vaccines that mainly activate humoral immunity, the dual activation mechanism of nucleic acid vaccines provides stronger immune protection.

 

  • Second, the preparation is simple, saving time and effort. Nucleic acid vaccines can be amplified in large quantities, the purification process is relatively simple, and they can be combined with a variety of recombinant plasmids encoding different antigen genes to prepare multivalent vaccines, reducing the consumption of manpower, material resources, and financial resources.

 

  • Third, cross-protection between the same species and different strains. Nucleic acid vaccine expression vectors can flexibly transform the target genes they carry and select antigenic determinants in a targeted manner, thereby achieving cross-protection against pathogens of the same species and different strains.

 

  • Fourth, it is safer to use. Protein antigens are expressed in host cells, and there is no risk of causing disease due to virulence reversion or residual virulence, nor will it cause serious adverse reactions in the body. The fifth is a lasting immune response. Nucleic acid vaccines have strong immune persistence and can obtain long-term immunity after one vaccination. The sixth is the expansion of treatment areas. Traditional vaccines are mainly used in the field of infectious disease prevention. Nucleic acid vaccines have successfully expanded their application scope to new fields such as tumor treatment, breaking the application limitations of traditional vaccines.

 

Nucleic acid vaccine technology research and development process

The research and development process of nucleic acid vaccines includes six core steps:

  • The first is antigen design and sequence screening. Based on the pathogen gene data, the target antigen (such as the new coronavirus S protein) is determined, the coding sequence is optimized through bioinformatics, the 5' cap structure, UTR region and codon preference of mRNA are adjusted, or a DNA plasmid containing a strong promoter is designed.

 

  • The second is nucleic acid synthesis. DNA vaccines are amplified and purified by Escherichia coli fermentation plasmids, while mRNA vaccines use in vitro transcription technology to synthesize modified RNA (such as pseudouridine substitution) and remove impurities such as double-stranded RNA.

 

  • The third is the construction of a delivery system. DNA vaccines rely on electroporation or chemical carriers to penetrate the cell membrane and nuclear membrane, and mRNA vaccines are encapsulated by lipid nanoparticles (LNPs), and nanoparticles are homogenized by microfluidics technology.

 

  • Fourth, in vitro validation. Transfect candidate vaccines into cell lines to detect antigen expression efficiency and innate immune activation (ELISA to measure cytokines)

 

  • Fifth, animal model evaluation, testing immunogenicity (neutralizing antibodies, T cell responses) and safety (local/systemic toxicity) in mice or non-human primates. Sixth, production process development. Establish modular production lines (such as continuous flow LNP synthesis), optimize purification processes (HPLC to remove impurities), and formulate quality control standards (nucleic acid integrity, sterility, LNP particle size detection) to lay the foundation for large-scale production.

 

Technical Challenges

Insufficient efficiency and targeting of delivery systems

  • Limited delivery efficiency For DNA vaccines, they must not only pass through the cell membrane, but also cross the nuclear membrane to enter the cell nucleus to function. Although electroporation technology can improve its efficiency of entering cells to a certain extent, this technology will cause damage to local tissues, making it necessary to use it with caution in clinical applications.

 

  • Although mRNA vaccines do not need to enter the cell nucleus, the current mainstream lipid nanoparticle (LNP) delivery system has a low cell uptake rate and an unsatisfactory intracellular release efficiency, which cannot fully stimulate the immune response.

 

  •  Poor organ targeting The current LNP delivery system has obvious organ targeting defects. It is more likely to be enriched in the liver in the body, making it difficult to achieve precise targeted delivery to other organs, such as the lungs expected by respiratory virus vaccines, and organs such as the spleen and lymph nodes that play a key role in the immune response.

 

  • For example, when developing mucosal immune vaccines against respiratory viruses, the vaccine needs to be accurately delivered to the lungs to stimulate an effective immune response, but it is difficult to achieve this goal with existing technologies.

 

Stability and storage and transportation bottlenecks

  • The low-temperature dependence dilemma of mRNA vaccines mRNA molecules are unstable and will be rapidly degraded as long as RNA enzymes are present in the environment, which makes mRNA vaccines extremely demanding on storage conditions and usually need to be stored in ultra-low temperature environments of -20°C to -70°C.

 

  • Although freeze-drying technology, such as the technology used in CureVac's second-generation vaccine, can improve this situation to a certain extent and increase the storage temperature to 2-8°C, the protective agent used in this technology is complex and expensive, which increases the production cost of the vaccine.

 

  • Contradiction between DNA vaccine stability and expression efficiency Compared with mRNA vaccines, plasmid DNA has better stability at room temperature and can be stored for a long time.

 

  • However, the expression efficiency in vivo is much lower than that of mRNA vaccines. In order to improve the delivery and expression efficiency of DNA vaccines, physical methods such as electroporation or gene guns are often required, but these methods are complicated to operate, have high requirements for equipment and operators, and face many difficulties in large-scale application, making it difficult to meet the needs of large-scale production and vaccination.

 

Long-term safety controversy mRNA vaccines have exposed some potential risks in actual applications, such as the induction of myocarditis and pericarditis.

 

biohazard transport

 

Although the incidence is low, about 0.003%, the specific mechanism of occurrence is still unclear. It is speculated that it may be related to the activation of innate immune responses by nucleic acid molecules or the induction of cross-immunity. As for DNA vaccines, although there is no clinical evidence to show that there is a risk of genomic integration, theoretically, this risk does exist.

  • Challenges of large-scale production and cost control 1. Process bottleneck of LNP production The key component of LNP, ionizable lipids, such as ALC-0315, has an extremely complex synthesis process and requires ultra-low temperature reaction conditions during the synthesis process.

 

  • This not only places extremely high requirements on the reaction equipment, but also has huge equipment investment costs, with a single production line costing more than $100 million. In addition, the PEG lipids in LNP may cause allergic reactions in actual applications.

 

  • Although alternative materials, such as PEGylated phospholipids, are being actively developed, the feasibility and effectiveness of these alternative materials in actual production processes still need to be further verified. 2. mRNA purification technology threshold In the process of in vitro transcription to generate mRNA, impurities such as double-stranded RNA will be produced, which will affect the safety and effectiveness of the vaccine.

 

  • At present, high-performance liquid chromatography (HPLC) technology is mainly used to purify mRNA, but this technology has obvious limitations. On the one hand, the purification efficiency of HPLC equipment is directly related to the quality of mRNA.

 

  • On the other hand, the production capacity of global HPLC equipment is limited. When producing nucleic acid vaccines on a large scale, it cannot meet the demand for rapid and large-scale purification of mRNA, which has become the main bottleneck restricting the expansion of nucleic acid vaccine production capacity.
Top

Which Instrument Is Used for Vessel Sealing?

In recent years, by virtue of its significant advantages, electrosurgical vessel sealer and divider instruments have played a key role in surgery and have been deeply integrated into a rang of specialized surgical procedures. The following outlines its specific applications and advantages in different surgical disciplines:

 

General Surgery: Rapid Sealing, Reduced Trauma
In cholecystectomy, where complex blood vessel network around gallbladder, the instruments can ensure rapid sealing and dividing of vessels, reducing bleeding, minimizing risks and improving visibility.

In herniorrhaphy, where the operative space is limited, the instruments’ precise control allows for safe tissue dissection in narrow spaces, minimizing damage to surrounding nerves and vessels and and supporting postoperative recovery.

 

Gynecologic Surgery: Precision operation for Reproductive Function Preservation

In hysterectomy, where the vessels surrounding uterus are intricate and densely distributed, electrosurgical vessel sealer and divider ensures accurate vessel sealing and dividing while minimizing thermal injury to surrounding organs.
In myomectomy, its adjustable energy output allows for precise fibroid removal while preserving as much healthy uterine tissue as possible, helping preserve future fertility.

 

Cardiothoracic Surgery: A Reliable Choice for High-Risk Areas
Cardiothoracic surgery demands high precision. With its accurate performance, the instruments can safely handle medium and small vessels in the hilum, ensuring sufficient sealing force to withstand intra-thoracic pressure changes.
In cardiac surgery, its pulsed energy release feature minimizes thermal conduction effect to myocardial tissue, enhancing surgical safety.

 

Urologic Surgery: Supporting Recovery, Reducing Risks
In prostatectomy, instruments’ precise seal performance helps preserve sexual nerve function and decrease risk of postoperative complications.
In nephrectomy, its rapid vessel handling properties shorten operative time and reduces renal thermal ischemic injury while combining with minimally invasive techniques.

 

With technology iteration, new generation instruments integrates intelligent feedback system which can monitor tissue status in real-time and adjust energy output automatically, further enhancing seal reliability. Clinical applications shows this technology effectively shortens surgery time, reduces complication rates, and accelerates patient recovery. In the future, through deep integration with digital technologies, the instruments will play a key role in more complex surgical scenarios.

Top